Product Name Clomifene citrate
Alias Clomid, Clomiphene citrate, Serpafar, Ovinum
CAS 50-41-9
EINECS 200-035-3
Purity 99%
Packing foil bag or tin.
Appearance White powder
Clomid is a mixed estrogen agonist/antagonist (activator/blocker) which, when bound to the estrogen receptor, puts it in a somewhat different conformation (shape) than does estradiol. The estrogen receptor requires binding of an estrogen or drug at its binding site and also the binding of any of several cofactors at different sites. Without the binding of the cofactor, the estrogen receptor is inactive. Different tissues use different cofactors. Some of these cofactors are able to bind to the estrogen receptor/Clomid complex, but others are blocked due to the change in shape. The result is that in some tissues Clomid acts as an antagonist – the cofactor used in that tissue cannot bind and so the receptor remains inactive – and in others Clomid acts as an agonist (activator), because the cofactors used in that tissue are able to bind.
Clomid, or Clomiphene Citrate, is a SERM (selective estrogen receptor modulator), so it’s in the same grouping as tamoxifen (nolvadex). It is the most widely prescribed drug for ovulation induction, which is useful for those who are infertile.
As a SERM by its design Clomid prevents estrogen from binding to the receptors by binding in its place thereby preventing estrogen from performing in an undesirable manner. It is commonly believed that the effects of Clomid include reducing the total amount of estrogen you have in your body; this is not true. Clomid does not reduce nor prohibit estrogen from existing; it simply binds in its place. To have a reducing and prohibiting effect one would need to supplement with other medications such as Aromatase Inhibitors.
